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Less well known but important developments in the history of malaria include the work of Richard Shultz of the Malaria Research Laboratory in Port Blair, India in the 1920s and 1930s. Shultz made major advances in the understanding of the biology of the malaria parasites and, at the same time, developed effective methods for eliminating malaria. He also promoted the use of insecticide in the control of malaria, his most important innovation being the use of DDT. Unfortunately, the irrational pursuit of DDT and other pesticides led to the destruction of millions of acres of valuable forest in the region around the Ganges river and led to the death or displacement of millions of people. This was a tragic mistake and one that the international public health community has yet to fully recover from. Shultz's discovery of the chloroquine resistance, in the early 1930s, was also an important development in the treatment of malaria. Chloroquine was first used as a medicine in India against malaria and was found to be effective. He later discovered that it was the most effective drug against malaria when given in the required dose and that it acted by killing the malaria parasites (which he had shown was the stage of the lifecycle that gave rise to the clinical symptoms of malaria). This discovery has led to a revolution in the treatment of malaria with the widespread use of chloroquine. Chloroquine was first introduced to the UK in 1946 and rapidly became the most widely used anti-malarial drug and was the only effective treatment for malaria until the discovery of resistance in the mid 1960s.
The next major challenge was to find an effective treatment of malaria, a problem that had plagued the medical profession since the discoveries of Louis Pasteur in 1881 and Robert Koch in 1882. In the years immediately following their discoveries, in the 1880s, the Pasteur Institute in France and the Royal Sanitary Institute in Berlin were both seeking new methods of combating malaria. The Pasteur Institute had already developed a vaccine for rabies, and in 1890, soon after the discovery of malaria, began to try to create a vaccine to protect against malaria. After much effort they succeeded [33].
9. Mission: Impossible - Rogue NationAlfredson's return to the franchise is not only the best in the series, but one of the best action movies of all time.
It is the fifth entry in the series, and the second installment of the sixth movie series in the entire franchise. Tom Cruise returns as Ethan Hunt, the character first introduced in the first film, Mission: Impossible. 827ec27edc